Prenatal determination of farm animal fetal sex using free fetal DNA in maternal plasma
نویسندگان
چکیده
In many farm animal species, the preference of a specific sex is obvious mainly due to commercial implications; so for comprehensive and efficient results in the livestock management plans specially breedingand selection programs, it is necessary to include acost-effective and reliable strategy for early determination of fetal sex. Several invasive and non-invasive approaches have been established for fetal gender detection in farm animals at early gestational age. Non-invasive determination of fetal sex based on analysis of cffDNA in maternal plasma would be a useful tool for management decisions andprovides opportunities for prenatal genetic diagnosis. Among the numerous demonstrated applications forcffDNA, early fetal sexing appears to be promising area for immediate application in farm animal industry. Still there is great potential for the continued application of this genetic material for prenatal fetal genetic evaluation. The significant contributions of cffDNA in general and its practical application in horse, cattle and sheep fetal gender detection in particular are collected in this paper.
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An Effective Method for Detecting Y-chromosome Specific Sequences of Circulating Fetal DNA in Maternal Plasma During the First-trimester
Background and Aims: New advances in the use of cell-free fetal DNA (cffDNA) in maternal plasma of pregnant women has provided the possibility of applying cffDNA in prenatal diagnosis as a non-invasive method. One of the applications of prenatal diagnosis is fetal gender determination. Early prenatal determination of fetal sex is required for pregnant women at risk of X-linked and some endocrin...
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